Mechanics of Nonfibrotic Adhesive Interfaces

Research overview

Fibrotic encapsulation remains a grand challenge for implanted materials. This work investigates a purely mechanical approach to durable biointerfaces, focusing on adhesion and interfacial mechanics as an alternative to biochemical interventions.

Mouse fibrotic tissue with DAPI in blue, α-SMA (AF488) in green, and CD45 (AF594) in orange. — Immunofluorescence image of mouse fibrotic tissue. Blue: DAPI; green (AF488): α-SMA; orange (AF594): CD45.

Related papers and references

The poster presents preliminary, ongoing research. The papers below are separate related studies.

Adhesive nonfibrotic bioelectronic interfaces on diverse peripheral nerves for long-term functional neuromodulation

Hyunmin Moon, Bastien F. G. Aymon, Jue Deng, Tao Zhou, Vincent Prevosto, Fan Wang, Jingjing Wu, Xuanhe Zhao

Science Advances 11(45), eadz3668 (2025).

Adhesive implant interfaces prevent fibrosis by disrupting mechanobiological feedback

Mohammad Jafari, Bastien F. G. Aymon, Yuan Hong, Delaram Shakiba, Guy M. Genin, Xuanhe Zhao, Farid Alisafaei

bioRxiv 2025.06.01.657311 (2025).

Preprint (not peer reviewed).

Dry double-sided tape for adhesion of wet tissues and devices

Hyunwoo Yuk, Claudia E. Varela, Christoph S. Nabzdyk, Xinyu Mao, Robert F. Padera, Ellen T. Roche, Xuanhe Zhao

Nature 575, 169–174 (2019).

Adhesive anti-fibrotic interfaces on diverse organs

Jingjing Wu, Jue Deng, Georgios Theocharidis, Tiffany L. Sarrafian, Leigh G. Griffiths, Roderick T. Bronson, Aristidis Veves, Jianzhu Chen, Hyunwoo Yuk, Xuanhe Zhao

Nature 630, 360–367 (2024).

Related tools and resources

ZSlide is an open-source viewer I’m developing for histology slides, with annotation, measurement, and region export tools.

View ZSlide on GitHub

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